Multiple Sclerosis | Stem Cells Australia

Condition

Multiple Sclerosis

Over 25,600 people in Australia and more than two million across the globe live with multiple sclerosis. Multiple Sclerosis (MS) is an autoimmune disease where a person’s immune system starts attacking and destroying what are known as ‘myelin sheaths’. Myelin is a fatty layer of tissue that wraps around and protects your nerve cells, or neurons. It also allows electrical signals or messages to pass more quickly between cells. When neurons lose their myelin, signals can’t be sent properly and the neurons begin to die. This leads to the symptoms of MS.

Depending on which nerves are damaged, people diagnosed with MS may experience from a range of symptoms, commonly involving problems with walking and sensation, bladder and bowel issues and fatigue. Every case is different. Not everyone with MS will experience these symptoms, and symptoms can vary in severity over time.

People living with MS are usually diagnosed as having one of three particular types of MS. Relapsing remitting MS is the most common form and is characterised by flare-ups where the body’s immune system attacks the brain, spinal cord and/or optic nerve resulting in symptoms. These attacks are also referred to as relapses and are followed by periods of recovery or remission as the body is able to naturally repair this damage. However, the repair is often incomplete. After repeated episodes of relapse, the affected nerves may die.

Once this happens, people enter the progressive phase of MS, where symptoms no longer come and go but get progressively worse over time. This is known as secondary progressive MS. More rarely people can be diagnosed with progressive MS right from the beginning of their symptoms, these people are given a diagnosis of primary progressive MS. In this form, symptoms are due to the damage to the underlying nerve cells and not primarily through the immune system.

sca cell images Multiple Sclerosis

How could stem cells help?

There is no known single cause of MS, although many genetic and environmental factors have been shown to contribute to its development. Scientists are using stem cells to learn more about this condition and to explore ways to treat MS.

Understanding the disease

Stem cells made from a person's own cells can be used to grow nerves and other cells in the lab. These cells can be used to study what happens to cells in MS.

Developing New Drugs

Studying stem cells in the lab may help to speed up the progress of drug development. Important information can be obtained more quickly using cells, before research on animals is required. Researchers are examining treatments and drugs that can harness and possibly increase the ability of brain cells to naturally repair myelin.

Preventing or Repairing Damage

It is possible to use certain types of stem cells to ‘reset’ the immune system (known as ‘immunomodulation’). The aim is to prevent the immune system from attacking the myelin, or reduce the amount of damage done. This approach has had positive results in early clinical trials for people with relapsing remitting MS and who have failed to respond to conventional drug therapy. This approach uses the person's own bone marrow cells and is referred to as Autologous Haematopoietic Stem Cell Transplantation (AHSCT).

In Australia, AHSCT is available at hospital transplantation clinics by referral from a neurologist. Use is restricted due to the dangerous side effects of this treatment. This treatment is not available for other forms of MS where damage has already occurred to the person's nerves. Future research may one day lead to ways to re-grow nerves or replace that have been lost.

What are the challenges?

Autoimmune diseases of all kinds are challenging to treat because the immune system attacks a person's own cells. Completely blocking the immune system is not a possible course of treatment, as then the person cannot fight infections or perform other functions that keep us healthy.

Another challenge to developing MS treatments is that there is no single pattern to what causes the immune system of a person to start attacking the myelin sheath; the trigger causing the disease could be totally different in each person. Scientists still don’t fully understand how myelin sheaths are created by the nervous system. This makes trying to develop treatments to repair myelin sheaths very difficult.

Where can I find out more about clinical trials?

There are a number of sites that list clinical trials, including the clinicaltrials.gov registry. Please note that the scientific justification for the intervention and the credentials of those offering the service may have NOT been fully evaluated by this registry and may not be a legitimate trial. Please consult with your medical specialist or general practitioner as they are best placed to advise you on whether you would be a good candidate for a trial given your circumstances. 

Please note: Although some clinics may claim to already offer stem cell treatments for MS, there are serious questions about the scientific rationale and the safety of many of these approaches. Currently, there are no proven, safe and effective stem cell treatment for all forms of MS. Also while AHSCT may be a suitable intervention for some people with relapsing remitting MS, other types of therapy that use the person's own cells from fat or other sources of stem cells may have no evidence that they work or are even safe.

Some of this material has been adapted from factsheets produced by EuroStemCell.org under a Creative Commons license.
Where else can I go to find out more?

Using stem cells in the brain to combat MS

Stem Cells Australia

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